![]() Mycobacterium avium subsp paratuberculosis (MAP) is the causative agent of Johne's disease, which is an economically and clinically relevant pathogen for commercial deer production. abscessus, highlighting their theranostic applications in medicine. Accordingly, this review aimed to introduce some potential mycobacteriophages in the research, specifically those that are infective to the three troublesome mycobacteria, M. smegmatis, more research is still ongoing to find mycobacteriophages specific to pathogenic mycobacteria, such as phage DS6A, which has been shown to be able to infect members of the M. Although the infectivity of the majority of discovered mycobacteriophages has been evaluated in non-pathogenic M. ![]() This is because mycobacteriophages, regardless of their cycle type (temperate/lytic), can tackle barriers in the mycobacterial cell wall and make the infected bacteria replicate phage DNA along with their DNA. ![]() Exploiting mycobacteriophages as viruses that infect mycobacteria has significantly accelerated the diagnosis and treatment of mycobacterial infections. Similarly, the susceptibility of nontuberculosis mycobacteria (NTM) to first-line tuberculosis antibiotics has also declined in recent years. tuberculosis (Mtb) infections are multi-drug resistant (MDR), and only 50% of positive MDR-Mtb cases are responsive to standard treatments. Moreover, recent studies depicted that more than 20% of M. Detection of mycobacterial infections is always demanding due to the intracellular nature of these pathogens that, along with the lipid-enriched structure of the cell wall, complicates the access to the internal contents of mycobacterial cells. The control of mycobacterial infections is influenced by the challenges faced in the diagnosis of these bacteria and the capability of these pathogens to develop resistance against common antibiotics. Some mycobacteria, such as Mycobacterium tuberculosis, promote the deaths of millions of lives throughout the world annually. Mycobacterial infections are a group of life-threatening conditions triggered by fast- or slow-growing mycobacteria. We recommend further investigations to understand the basis of the observed host preference in mycobacteriophages, evaluate combinatorial therapy of phages and antibiotics, and screen the phages for undesirable genes. Overall, our findings demonstrate the antibiofilm potential of mycobacteriophages and continue to endorse mycobacteriophage therapy as a treatment alternative to our failing antibiotic arsenal. If accurate, this finding could have profound implications for both diagnostic and therapeutic applications of mycobacteriophages. Furthermore, based on our host range data, we hypothesize that mycobacteriophages might have a preference for Mtb hosts from pulmonary infection sites compared to those from extrapulmonary sites. We demonstrate that multiplicity of infection and the age of the biofilms are significant determinants of phage antibiofilm activity. Here we investigated the in-vitro activity of a three-phage cocktail against biofilms of forty-six clinically isolated Mtb using the MBEC biofilm device. Antibiofilm activity, therefore, is a highly sought-after characteristic of mycobacteriophages intended for therapeutic use. Mycobacteriophage therapy, as an up-and-coming technology, is envisaged to revolutionize the treatment of tuberculosis (TB), particularly involving antibiotic-resistant Mtb. However, unlike other bacteria, mycobacterial biofilms tend to be very rich in lipids, and this accords them much more resilience than their carbohydrate-based counterparts’. With a focus on roads, traffic infrastructure, signage, and other public infrastructure, RapidMap is dedicated to supporting government and council efforts to ensure the continued viability of these public structures with accurate geospatial data attributes.Biofilm formation has been shown to be a very effective survival mechanism used by many bacteria pathogens, including Mycobacterium tuberculosis (Mtb). All of this is achieved through the utilisation of AI-supported 3D geospatial data models that allow for complex mapping of dilapidation, as well as shifts in environmental conditions that may impact the asset. Being a geospatial solutions company first and foremost, RapidMap provides data services that are more shareable, collaborative, and actionable than more traditional 2D data forms. This is where asset data inspection services like RapidMap come into play, offering a more comprehensive, accurate method of collecting, managing, and consolidating asset management data for both businesses and government bodies. As Australia’s infrastructure ages and is built to accommodate urban growth, more complex mapping and asset management systems are required to keep up with data tracking and planning maintenance.
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